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Conversely, knockdown of FGF21 in mice fed a ketogenic diet significantly increases serum lipemia and cholesterolemia ( Fibroblast Growth Factor 21 Protects Other Organs Stressed by Chronic Energy Excess and Metabolic Dysfunction Pancreas By sensitizing adipose tissue and skeletal muscle to insulin, FGF21 reduces demand for insulin secretion, in turn lessening demand for energy generation by cells

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